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Background
Patients with inflammatory breast cancer (IBC) have a high risk of central nervous system metastasis (mCNS). The purpose of this study was to quantify the incidence of and identify risk factors for mCNS in patients with IBC.
Methods
The authors retrospectively reviewed patients diagnosed with IBC between 1997 and 2019. mCNS‐free survival time was defined as the date from the diagnosis...
Background
Low‐dose azacitidine (AZA) regimens, primarily 5‐day AZA, have been used in lower risk myelodysplastic syndrome (LrMDS) but they have yet to be directly compared to the standard 7‐day, uninterrupted dosing schedule.
Method
In this phase 2, multicenter, randomized trial, 55 patients with adult LrMDS (low and intermediate‐1 risk by international prognostic scoring system [IPSS]) were randomly...
It has been 46 years since the launch of cancer control programs in India and yet the recent National Family Health Survey (fifth round, 2019–2021) has reported that just 1.9% of women aged 30–49 years have ever undergone cervical cancer screening. The cost of delayed diagnosis of cervical cancer and its treatment is overwhelming, and the rural population takes the worst hit. It is the need of the hour...
Background
Risk assessment for breast cancer–related lymphedema has emphasized upper‐limb symptoms and treatment‐related risk factors. This article examined breast cancer–related lymphedema after surgery, overall and in association with broader demographic and clinical features.
Methods
The Carolina Breast Cancer Study phase 3 followed participants for breast cancer–related lymphedema from baseline...
In their fiscal year 2021 reports, the US House and Senate Appropriations Committees requested that the National Institutes of Health (NIH) evaluate current research related to women's health and topics that include stagnant cervical cancer survival. In response, the NIH Office of Research on Women's Health, with input from women's health experts; members of the public; representatives from NIH institutes,...
Chimeric antigen receptor (CAR) T‐cell therapy, antibody–drug conjugates, bispecific T‐cell redirectors, and agents targeting tonic B‐cell receptor signaling have altered the paradigm for three of the most common lymphomas in the year 2021. For diffuse large B‐cell lymphoma, the POLARIX study has shown improvement on the standard backbone of rituximab plus cyclophosphamide, doxorubicin, vincristine,...
Background
Infections cause significant treatment‐related morbidity during pediatric acute lymphoblastic leukemia/lymphoma (ALL/LLy) therapy. Fevers during periods without severe neutropenia are common, but etiologies are not well‐described. This study sought to describe the bloodstream infection (BSI) and non‐BSI risk in children undergoing therapy for ALL/LLy.
Methods
Demographic and clinical...
Background
The survival of patients with localized embryonal rhabdomyosarcoma (RMS) completely resected at diagnosis is greater than 90%. Most patients have paratesticular, uterine, or vaginal RMS, limiting specific analyses of RMS localized in other anatomic regions. This international study was conducted to define the outcome for completely resected embryonal RMS at sites other than paratesticular,...
Background
Biobehavioral factors such as social isolation and depression have been associated with disease progression in ovarian and other cancers. Here, the authors developed a noninvasive, exosomal RNA profile for predicting ovarian cancer disease progression and subsequently tested whether it increased in association with biobehavioral risk factors.
Methods
Exosomes were isolated from plasma...
Cervical cancer is associated with profound socioeconomic and racial disparities in incidence, mortality, morbidity, and years of life lost. The last standard‐of‐care treatment innovation for locally advanced cervical cancer occurred in 1999, when cisplatin chemotherapy was added to pelvic radiation therapy (chemoradiation therapy). Chemoradiation therapy is associated with a 30%–50% failure rate,...
Background
Primary malignant mediastinal germ cell tumors (GCTs) are rare pediatric tumors that have a poorer prognosis compared to GCTs occurring elsewhere in the body. The current study aimed to assess the prognostic factors and treatment outcomes of children with primary malignant mediastinal GCT in Taiwan.
Methods
The authors retrospectively reviewed children 0–18 years old who were newly diagnosed...
Background
Metastatic spine tumor surgery consists of palliative operations performed on frail patients with multiple medical comorbidities. Enhanced recovery after surgery (ERAS) programs involve an evidence‐based, multidisciplinary approach to improve perioperative outcomes. This study presents clinical outcomes of a metastatic spine tumor ERAS pathway implemented at a tertiary cancer center.
...
Effective screening and vaccination programs can potentially eliminate cervical cancer in the future; however, to accomplish this goal, we have to be able to offer services to all girls and women.
In particular, women who live in rural areas and women who have low socioeconomic status are at highest risk.
Efforts are required to improve access to care at all levels for these women at risk.
...
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